Praneetha started her career as an actor in the 2010 Kannada film Porki, a remake of the Telugu blockbuster Pokiri, opposite Darshan. After the success of Porki, Praneetha refused several offers from Kannada films and became choosy about her projects before signing the Telugu film Baava, a love story where she starred opposite Siddharth. Praneetha was praised unanimously for her portrayal of a Telugu village belle in the film. Praneetha went on to appear in her first Tamil film, Udhayan starring Arulnithi.

Praneetha was then signed up for her second Tamil project Saguni opposite Karthi which released in both Tamil and Telugu languages. Saguni was her biggest release: a film that released in a record 1,150 theaters all over the world and 450 theaters alone in Telugu language. It was the highest Tamil movie to do so after Rajnikanth’s Robot.

Praneetha then appeared in Jarasandha and Bheema Theeradalli, a real life story of a naxalite, both opposite Duniya Vijay. The latter saw massive success in Karnataka. Praneetha was praised for her portrayal of Bheemavva by critics and won a Filmfare nomination for the same